Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 13 Researches
7.3
USERS' SCORE
Good
Based on 5 Reviews
8
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Lutein (Free Lutein)(from Lutein Esters)(from Marigold Flowers Extract) (Tagetes erecta)
10 mg
**
Top Medical Research Studies
8
We explored the relationship between serum levels of carotenoids, like lutein, and cardiovascular-kidney-metabolic syndrome in over 1,600 U.S. adults. Through extensive analysis, we found that higher lutein levels corresponded with a lower likelihood of advanced CKM syndrome. Other carotenoids also showed similar protective effects, but β-cryptoxanthin did not demonstrate any significant benefit. This suggests that increasing intake of carotenoids, especially lutein, may be a smart choice for heart health.
Read More
8
We aimed to investigate how levels of certain carotenoids impact mortality rates in adults with metabolic dysfunction-associated fatty liver disease (MAFLD). Our analysis involved over 3,000 participants and focused on deaths from all causes, including cardiovascular issues.
Interestingly, higher levels of lutein and other carotenoids correlated with a lower risk of death. Specifically, those with the highest lutein levels were 38% less likely to die from cardiovascular disease compared to those with the lowest levels. However, it's important to note that while the correlation exists, we cannot definitively claim that lutein directly prevents heart disease based on this study alone.
Interestingly, higher levels of lutein and other carotenoids correlated with a lower risk of death. Specifically, those with the highest lutein levels were 38% less likely to die from cardiovascular disease compared to those with the lowest levels. However, it's important to note that while the correlation exists, we cannot definitively claim that lutein directly prevents heart disease based on this study alone.
Read More
8
Supplementation reduces inflammation markers
In our double-blind, placebo-controlled study, we assessed the effects of lutein, zeaxanthin, and meso-zeaxanthin on cardiovascular inflammation and oxidative processes. Participants received either the active supplement or a placebo for six months.
We found significant reductions in key inflammatory markers and oxidized LDL in those taking the supplement. These results suggest that lutein and its companions may help combat inflammation, potentially contributing to healthier cardiovascular systems by supporting lower levels of harmful lipid oxidation.
We found significant reductions in key inflammatory markers and oxidized LDL in those taking the supplement. These results suggest that lutein and its companions may help combat inflammation, potentially contributing to healthier cardiovascular systems by supporting lower levels of harmful lipid oxidation.
Read More
Most Useful Reviews
9
Tired eyes improved
3 people found this helpful
I started noticing dryness and fatigue in my eyes from multiple hours in air-conditioned environments. Since taking lutein, my symptoms have significantly improved. I intend to continue using it as a preventative measure against eye diseases, while being cautious about dosage.
Read More
7.5
Effective for cataracts
I find that lutein has been effective in preventing cataracts and supporting macular health.
Read More
6
Eased eye dryness
Since taking lutein, I've experienced a noticeable reduction in dry eyes over time.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 13 Researches
7.3
- All Researches
9
We explored the potential of lutein, a powerful antioxidant, in treating myocardial ischemia-reperfusion injury. To enhance its effectiveness, a novel delivery system named lutein@DTPP was developed, allowing for targeted administration directly to heart tissues.
Our findings showed that this method improved mitochondrial function in heart cells, crucial for reducing damage and preventing cell death. However, while lutein demonstrated benefits in this context, it's important to note that the study primarily focused on a specific injury model, and broader effects on cardiovascular disease might still require more investigation.
Our findings showed that this method improved mitochondrial function in heart cells, crucial for reducing damage and preventing cell death. However, while lutein demonstrated benefits in this context, it's important to note that the study primarily focused on a specific injury model, and broader effects on cardiovascular disease might still require more investigation.
Read More
8
We explored the relationship between serum levels of carotenoids, like lutein, and cardiovascular-kidney-metabolic syndrome in over 1,600 U.S. adults. Through extensive analysis, we found that higher lutein levels corresponded with a lower likelihood of advanced CKM syndrome. Other carotenoids also showed similar protective effects, but β-cryptoxanthin did not demonstrate any significant benefit. This suggests that increasing intake of carotenoids, especially lutein, may be a smart choice for heart health.
Read More
8
We aimed to investigate how levels of certain carotenoids impact mortality rates in adults with metabolic dysfunction-associated fatty liver disease (MAFLD). Our analysis involved over 3,000 participants and focused on deaths from all causes, including cardiovascular issues.
Interestingly, higher levels of lutein and other carotenoids correlated with a lower risk of death. Specifically, those with the highest lutein levels were 38% less likely to die from cardiovascular disease compared to those with the lowest levels. However, it's important to note that while the correlation exists, we cannot definitively claim that lutein directly prevents heart disease based on this study alone.
Interestingly, higher levels of lutein and other carotenoids correlated with a lower risk of death. Specifically, those with the highest lutein levels were 38% less likely to die from cardiovascular disease compared to those with the lowest levels. However, it's important to note that while the correlation exists, we cannot definitively claim that lutein directly prevents heart disease based on this study alone.
Read More
8
Supplementation reduces inflammation markers
In our double-blind, placebo-controlled study, we assessed the effects of lutein, zeaxanthin, and meso-zeaxanthin on cardiovascular inflammation and oxidative processes. Participants received either the active supplement or a placebo for six months.
We found significant reductions in key inflammatory markers and oxidized LDL in those taking the supplement. These results suggest that lutein and its companions may help combat inflammation, potentially contributing to healthier cardiovascular systems by supporting lower levels of harmful lipid oxidation.
We found significant reductions in key inflammatory markers and oxidized LDL in those taking the supplement. These results suggest that lutein and its companions may help combat inflammation, potentially contributing to healthier cardiovascular systems by supporting lower levels of harmful lipid oxidation.
Read More
8
Our analysis focused on how carotenoid intake relates to abdominal aortic calcification (AAC), a crucial indicator of cardiovascular risk. In a study with 2,889 participants, we found that increased consumption of carotenoids—particularly lutein and zeaxanthin—was linked to a reduced risk of severe AAC.
Results showed that higher intakes of various carotenoids, including lutein, significantly lowered the odds of AAC, emphasizing the potential heart health benefits of these nutrients. This suggests that including more carotenoid-rich foods in our diet might be beneficial for our cardiovascular health.
Results showed that higher intakes of various carotenoids, including lutein, significantly lowered the odds of AAC, emphasizing the potential heart health benefits of these nutrients. This suggests that including more carotenoid-rich foods in our diet might be beneficial for our cardiovascular health.
Read More
User Reviews
USERS' SCORE
Good
Based on 5 Reviews
8
- All Reviews
- Positive Reviews
- Negative Reviews
9
Tired eyes improved
3 people found this helpful
I started noticing dryness and fatigue in my eyes from multiple hours in air-conditioned environments. Since taking lutein, my symptoms have significantly improved. I intend to continue using it as a preventative measure against eye diseases, while being cautious about dosage.
Read More
7.5
Effective for cataracts
I find that lutein has been effective in preventing cataracts and supporting macular health.
Read More
6
Eased eye dryness
Since taking lutein, I've experienced a noticeable reduction in dry eyes over time.
Read More
6
Preventative benefits observed
9 people found this helpful
I drink this supplement daily to help my mother, who suffers from glaucoma and cataracts. It appears to lessen her visual disturbances. Although I haven't noticed any immediate impact, its overall efficacy seems beneficial for prevention with regular use.
Read More
7.5
Prevention against eye diseases
3 people found this helpful
I chose lutein specifically for its benefits for dry eyes. It has proven effective, allowing me to reduce my reliance on eye drops. I plan to keep using it as I age, aiming to prevent potential eye diseases.
Read More
Frequently Asked Questions
9
Tired eyes improved
3 people found this helpful
I started noticing dryness and fatigue in my eyes from multiple hours in air-conditioned environments. Since taking lutein, my symptoms have significantly improved. I intend to continue using it as a preventative measure against eye diseases, while being cautious about dosage.
6
Eased eye dryness
Since taking lutein, I've experienced a noticeable reduction in dry eyes over time.
7.5
Effective for cataracts
I find that lutein has been effective in preventing cataracts and supporting macular health.
6
Preventative benefits observed
9 people found this helpful
I drink this supplement daily to help my mother, who suffers from glaucoma and cataracts. It appears to lessen her visual disturbances. Although I haven't noticed any immediate impact, its overall efficacy seems beneficial for prevention with regular use.
7.5
Prevention against eye diseases
3 people found this helpful
I chose lutein specifically for its benefits for dry eyes. It has proven effective, allowing me to reduce my reliance on eye drops. I plan to keep using it as I age, aiming to prevent potential eye diseases.
8
We examined the effects of serum carotenoids, specifically lutein, on cardiovascular disease (CVD) risk using a robust data set from the National Health and Nutrition Examination Survey.
Our analysis of over 12,000 participants revealed that higher levels of lutein were linked to a lower prevalence of CVD, including a significant reduction in risks of heart attack and stroke.
Although lutein shows promise, it’s essential to remember that these findings indicate correlation, not causation, and we can't say for certain that lutein directly prevents heart disease.
Our analysis of over 12,000 participants revealed that higher levels of lutein were linked to a lower prevalence of CVD, including a significant reduction in risks of heart attack and stroke.
Although lutein shows promise, it’s essential to remember that these findings indicate correlation, not causation, and we can't say for certain that lutein directly prevents heart disease.
7
We examined the link between serum carotenoids, including lutein, and mortality in patients with metabolic syndrome (MetS). Our study involved over 2,500 MetS patients and utilized advanced statistical methods to analyze data from multiple years.
We found that higher levels of certain carotenoids were generally protective against mortality, specifically linking lutein to lower death rates. However, this beneficial effect appeared reduced in patients taking lipid-lowering medications.
This suggests that incorporating carotenoid-rich foods could be especially important for MetS patients on such drugs.
We found that higher levels of certain carotenoids were generally protective against mortality, specifically linking lutein to lower death rates. However, this beneficial effect appeared reduced in patients taking lipid-lowering medications.
This suggests that incorporating carotenoid-rich foods could be especially important for MetS patients on such drugs.
8
Supplementation reduces inflammation markers
In our double-blind, placebo-controlled study, we assessed the effects of lutein, zeaxanthin, and meso-zeaxanthin on cardiovascular inflammation and oxidative processes. Participants received either the active supplement or a placebo for six months.
We found significant reductions in key inflammatory markers and oxidized LDL in those taking the supplement. These results suggest that lutein and its companions may help combat inflammation, potentially contributing to healthier cardiovascular systems by supporting lower levels of harmful lipid oxidation.
We found significant reductions in key inflammatory markers and oxidized LDL in those taking the supplement. These results suggest that lutein and its companions may help combat inflammation, potentially contributing to healthier cardiovascular systems by supporting lower levels of harmful lipid oxidation.
8
We aimed to investigate how levels of certain carotenoids impact mortality rates in adults with metabolic dysfunction-associated fatty liver disease (MAFLD). Our analysis involved over 3,000 participants and focused on deaths from all causes, including cardiovascular issues.
Interestingly, higher levels of lutein and other carotenoids correlated with a lower risk of death. Specifically, those with the highest lutein levels were 38% less likely to die from cardiovascular disease compared to those with the lowest levels. However, it's important to note that while the correlation exists, we cannot definitively claim that lutein directly prevents heart disease based on this study alone.
Interestingly, higher levels of lutein and other carotenoids correlated with a lower risk of death. Specifically, those with the highest lutein levels were 38% less likely to die from cardiovascular disease compared to those with the lowest levels. However, it's important to note that while the correlation exists, we cannot definitively claim that lutein directly prevents heart disease based on this study alone.
References
- Sun L, He Z, Li Y, Huo Z, Liu L. The relationship between nutrient intake, lifestyle, and non-alcoholic fatty liver disease in patients with type 2 diabetes mellitus: Results from the National Health and Nutrition Examination Surveys 2007-2018. Clin Nutr ESPEN. 2025;66:446. 10.1016/j.clnesp.2025.02.008
- Li C, Liang Y, Lu Q, Lin Y, Wen S, et al. Protective effect of serum carotenoids on mortality among metabolic syndrome patients: attenuated by lipid-lowering drugs. Nutr J. 2025;24:27. 10.1186/s12937-025-01092-x
- Chen M, Cai S, Jia Q, Suo Y, Tang Y, et al. Inverse Relationship Between Serum Carotenoid Levels and Cardiovascular-Kidney-Metabolic Syndrome Among the General Adult Population. J Diabetes. 2025;17:e70046. 10.1111/1753-0407.70046
- Shi P, Sha Y, Wang X, Yang T, Wu J, et al. Targeted Delivery and ROS-Responsive Release of Lutein Nanoassemblies Inhibit Myocardial Ischemia-Reperfusion Injury by Improving Mitochondrial Function. Int J Nanomedicine. 2024;19:11973. 10.2147/IJN.S488532
- Lin B, Liu Z, Li D, Zhang T, Yu C. Associations of serum carotenoids with all-cause and cardiovascular mortality in adults with MAFLD. Nutr Metab Cardiovasc Dis. 2024;34:2315. 10.1016/j.numecd.2024.06.001
- Stringham NT, Green M, Roche W, Prado-Cabrero A, Mulcahy R, et al. Lutein, zeaxanthin, and meso-zeaxanthin supplementation attenuates inflammatory cytokines and markers of oxidative cardiovascular processes in humans. Nutr Metab Cardiovasc Dis. 2024;34:1976. 10.1016/j.numecd.2024.05.009
- Masle AM, Kibel A, Jukić I, Čičak P, Selthofer-Relatić K, et al. Enhancing Endothelial Function with Nutrient-Enriched Table Hen Eggs: A Randomized Study in Patients Recovering from Acute Coronary Syndrome. Clin Interv Aging. 2024;19:953. 10.2147/CIA.S461821
- Chen W, Li Y, Li M, Li H, Chen C, et al. Association between dietary carotenoid intakes and abdominal aortic calcification in adults: National Health and Nutrition Examination Survey 2013-2014. J Health Popul Nutr. 2024;43:20. 10.1186/s41043-024-00511-9
- Kolar L, Šušnjara P, Stupin M, Stupin A, Jukić I, et al. Enhanced Microvascular Adaptation to Acute Physical Stress and Reduced Oxidative Stress in Male Athletes Who Consumed Chicken Eggs Enriched with n-3 Polyunsaturated Fatty Acids and Antioxidants-Randomized Clinical Trial. Life (Basel). 2023;13. 10.3390/life13112140
- Ba W, Xu W, Deng Z, Zhang B, Zheng L, et al. The Antioxidant and Anti-Inflammatory Effects of the Main Carotenoids from Tomatoes via Nrf2 and NF-κB Signaling Pathways. Nutrients. 2023;15. 10.3390/nu15214652
- Wang M, Tang R, Zhou R, Qian Y, Di D. The protective effect of serum carotenoids on cardiovascular disease: a cross-sectional study from the general US adult population. Front Nutr. 2023;10:1154239. 10.3389/fnut.2023.1154239
- Šušnjara P, Mihaljević Z, Stupin A, Kolobarić N, Matić A, et al. Consumption of Nutritionally Enriched Hen Eggs Enhances Endothelium-Dependent Vasodilation via Cyclooxygenase Metabolites in Healthy Young People-A Randomized Study. Nutrients. 2023;15. 10.3390/nu15071599
- Zhu X, Cheang I, Tang Y, Shi M, Zhu Q, et al. Associations of Serum Carotenoids With Risk of All-Cause and Cardiovascular Mortality in Hypertensive Adults. J Am Heart Assoc. 2023;12:e027568. 10.1161/JAHA.122.027568
